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Single and joint effects of HHCB and cadmium on zebrafish (
Lei ZHANG, Jing AN, Qixing ZHOU
《环境科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 360-372 doi: 10.1007/s11783-011-0353-z
关键词: 1 3 4 6 7 8-hexahydro-4 6 6 7 8 8-hexamethylcyclopenta-gamma-2-benzopyran (HHCB) cadmium (Cd) antioxidant biomarker feculent water containing bedloads
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis
《医学前沿(英文)》 2022年 第16卷 第2期 页码 216-226 doi: 10.1007/s11684-022-0920-7
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Late embryogenesis abundant (LEA) genes encode highly hydrophilic proteins that are essential in abiotic stress responses. However, most LEA genes in higher plants have not yet been investigated. This study identified an LEA family gene (PtrLEA7) from Poncirus trifoliata and studied its function in drought tolerance. The full-length coding sequence of PtrLEA7 was 420 bp encoding a protein of 139 amino acids. Phylogenetic analysis shows that PtrLEA7 protein belongs to the LEA_4 subfamily. Expression profiling by qPCR found that PtrLEA7 was strongly induced by dehydration, cold and ABA treatments, and slightly induced by salt stress. Subcellular localization reveals that PtrLEA7 protein was located in both cytoplasm and nucleus. To investigate its function, transgenic plants of both tobacco and Poncirus trifoliata overexpressing PtrLEA7 were obtained. Stress tolerance assays show that overexpression lines had enhanced dehydration and drought tolerance compared with wild type plants, indicating that PtrLEA7 positively regulates drought tolerance. In addition, transgenic plants had much higher expression levels of three antioxidant enzyme genes (CAT, SOD and POD) and significantly increased catalase enzyme activity, accompanied by reduced reactive oxygen species accumulation in comparison with wild type plants. Collectively, this study demonstrates that PtrLEA7 can confer enhanced drought tolerance partially via enhancing antioxidant capacity.
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
《环境科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 99-105 doi: 10.1007/s11783-013-0490-7
Polyamines and antioxidant defense system are associated with cold tolerance in centipedegrass
Jingjing CHEN, Junyang FANG, Zhenfei GUO, Shaoyun LU
《农业科学与工程前沿(英文)》 2018年 第5卷 第1期 页码 129-138 doi: 10.15302/J-FASE-2017197
关键词: antioxidants centipedegrass chilling photosynthesis polyamines
Tonglu WEI, Dalong GUO, Jihong LIU
《农业科学与工程前沿(英文)》 页码 236-246 doi: 10.15302/J-FASE-2020368
关键词: abiotic stress antioxidant drought late embryogenesis abundant Poncirus trifoliata
Plasma transthyretin is a nutritional biomarker in human morbidities
《医学前沿(英文)》 2022年 第16卷 第4期 页码 540-550 doi: 10.1007/s11684-022-0940-3
关键词: lean body mass nutritional status transthyretin malnutrition inflammation amyloidosis
Biosensor-based assay of exosome biomarker for early diagnosis of cancer
《医学前沿(英文)》 2022年 第16卷 第2期 页码 157-175 doi: 10.1007/s11684-021-0884-z
Changlin Cao, Jingxian Gu, Jingyao Zhang
《医学前沿(英文)》 2017年 第11卷 第2期 页码 169-177 doi: 10.1007/s11684-017-0505-z
关键词: soluble triggering receptor expressed on myeloid cells-1 infectious diseases diagnosis and prognosis biomarker
《医学前沿(英文)》 2022年 第16卷 第5期 页码 723-735 doi: 10.1007/s11684-021-0905-y
关键词: amyotrophic lateral sclerosis coronin-1a autophagy pathogenesis
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 278-285 doi: 10.1007/s11684-016-0453-z
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. We aimed to find novel molecules as potential biomarkers for the early diagnosis of CRC. A serum-free conditioned medium was successfully collected from three pairs of CRC tissue and adjacent normal tissue. iTRAQ-based quantitative proteomic analysis was applied to compare the differences in secretome between primary CRC mucosa and adjacent normal mucosa. A total of 145 kinds of proteins were identified. Of these proteins, 29 were significantly different between CRC and normal tissue. Tropomyosin 2 β (TPM2) exhibited the most significant differences; as such, this protein was selected for further validation. Quantitative real-time PCR indicated that the mRNA expression of TPM2 significantly decreased in the CRC tissue compared with the paired adjacent normal tissue. Immunohistochemical analysis also confirmed that TPM2 was barely detected at protein levels in the CRC tissue. In summary, this study revealed potential molecules for future biomarker applications and provided an efficient approach for the differential analysis of cancer-associated secretome. TPM2 may be valuable for the early diagnosis of CRC.
Xiaohong Kou,Lihua Han,Xingyuan Li,Zhaohui Xue,Fengjuan Zhou
《化学科学与工程前沿(英文)》 2016年 第10卷 第1期 页码 108-119 doi: 10.1007/s11705-016-1553-7
关键词: crude polyphenol extract purified polyphenol extract blueberry antioxidant antitumor immunity
Inhibition of NO emission by adding antioxidant mixture in
A. PRABU,R. B. ANAND
《能源前沿(英文)》 2015年 第9卷 第2期 页码 238-245 doi: 10.1007/s11708-015-0356-8
关键词: NO emission antioxidants Succinimide N N-dimethyl-p-phenylenediamine-dihydrochloride N-phenyl-p-phenylenediamine
Sepsis biomarkers: an omics perspective
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 58-67 doi: 10.1007/s11684-014-0318-2
Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics. The combination of these technologies can help refine the diagnosis of sepsis. This review paper serves as a reference for future studies that employ an integrated, multi-omics approach to disease identification.
关键词: sepsis biomarker genomics transcriptomics proteomics metabolomics
U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen
Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang
《环境科学与工程前沿(英文)》 2016年 第10卷 第6期 doi: 10.1007/s11783-016-0880-8
关键词: miRNA Prostate Estradiol Nonmonotonic dose-response Estrogenicity Drosha
标题 作者 时间 类型 操作
EMBRYOGENESIS ABUNDANT FAMILY GENE FROM PONCIRUS TRIFOLIATA, CONFERS ENHANCED DROUGHT TOLERANCE BY ENHANCING ANTIOXIDANT
期刊论文
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
期刊论文
Polyamines and antioxidant defense system are associated with cold tolerance in centipedegrass
Jingjing CHEN, Junyang FANG, Zhenfei GUO, Shaoyun LU
期刊论文
Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis
Changlin Cao, Jingxian Gu, Jingyao Zhang
期刊论文
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker
期刊论文
iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic biomarker
null
期刊论文
Antioxidant and antitumor effects and immunomodulatory activities of crude and purified polyphenol extract
Xiaohong Kou,Lihua Han,Xingyuan Li,Zhaohui Xue,Fengjuan Zhou
期刊论文